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A2.3 Viruses

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Higher Level 
Introduction to Viruses

A virus is a microscopic infectious agent that is fundamentally different from living cells. It is not considered a living organism because it lacks the cellular machinery required for metabolism, energy production, and independent reproduction. Instead, viruses are obligate intracellular parasites, meaning they can only reproduce by infecting a host cell and hijacking its molecular machinery.

Higher Level 
Higher Level 
Structural features of Viruses
  • Very small size (much smaller than bacteria).

  • No growth or metabolic processes on their own.

  • Nucleic acid: either DNA or RNA (not both).

  • Capsid: protein coat enclosing the genetic material.

  • No cytoplasm, organelles, or viral enzymes (until inside host).

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Higher Level 
Higher Level 
Higher Level 
Diversity Among Viruses

1. Genetic Material

May contain DNA or RNA, and it can be single or double stranded.

  • Further variation in how RNA is processed:

    • Positive-sense RNA: acts directly as mRNA.

    • Negative-sense RNA: must be transcribed to mRNA.

    • Retroviruses: RNA → DNA via reverse transcriptase (e.g. HIV).

2. Enveloped vs. Non-Enveloped

  • Enveloped viruses: have a lipid membrane derived from the host.

  • Non-enveloped viruses: lack a membrane, typically more stable.

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Higher Level 
Examples
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Higher Level 
Lytic vs Lysogenic Cycles

Lytic Cycle: Occurs mostly in plants and animals. Leads to host cell lysis.

Steps:

  1. Attachment

  2. DNA Entry

  3. DNA Replication

  4. Transcription

  5. Protein Synthesis (self-assembly)

  6. Lysis (break host membrane)

  7. Spread to nearby cells

Lysogenic Cycle: Virus integrates DNA into host genome and remains dormant & can later activate and enter lytic cycle.

Steps:

  1. Attachment

  2. DNA Entry

  3. Integration via integrase enzyme

  4. (→ Viral DNA inserted at a specific site in host chromosome)

Temperate viruses: do not lyse host immediately (e.g., phage λ).

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Higher Level 
Higher Level 
Evidence for origin of viruses

Progressive Hypothesis: Viruses evolved from mobile genetic elements (e.g., plasmids).

Regressive Hypothesis: Viruses were once free-living cells that lost complexity over time.

Higher Level 
Higher Level 
Rapid Evolution of Viruses

Viruses mutate rapidly due to:

    • Short generation times

    • High mutation rates

    • Strong natural selection pressure

Higher Level 
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